Cerebral Amyloid Deposition and Serotoninergic Innervation in Parkinson Disease
نویسندگان
چکیده
منابع مشابه
Cerebral amyloid deposition and serotoninergic innervation in Parkinson disease.
BACKGROUND Prior studies suggest that serotoninergic neurotransmission reduces β-amyloid (Aβ) production. OBJECTIVE To determine whether serotoninergic system degeneration in Parkinson disease promotes Aβ deposition, using in vivo positron emission tomographic probes of serotonin system integrity and Aβ deposition. DESIGN, SETTING, AND PATIENTS Cross-sectional study of 13 subjects with Parkinso...
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Alzheimer's disease (AD), a progressive neurodegenerative disorder, accounts for approximately 60 percent of all victims of dementia and affects greater than 10 percent of the population over 65 years old. Although the cause is unknown, there is evidence that beta-amyloid plays an important role in its pathogenesis. The deposition of this type of amyloid in the brain and its implications in AD ...
متن کاملLETTER TO THE EDITOR Striatal A-Amyloid Deposition in Parkinson Disease With Dementia
In a recent article, Kalaitzakis et al (1) reported a significantly greater amyloid-A peptide (AA) burden in the striatum of cases of Parkinson disease (PD) with dementia (PDD) than in nondemented PD patients, whereas >synuclein (>SN) and tau deposition were similarly rare in both groups. Because neuritic Braak stages were rather low in both groups, it was concluded that AA deposition in the st...
متن کاملLETTER TO THE EDITOR Striatal A-Amyloid Deposition in Parkinson Disease With Dementia
In a recent article, Kalaitzakis et al (1) reported a significantly greater amyloid-A peptide (AA) burden in the striatum of cases of Parkinson disease (PD) with dementia (PDD) than in nondemented PD patients, whereas >synuclein (>SN) and tau deposition were similarly rare in both groups. Because neuritic Braak stages were rather low in both groups, it was concluded that AA deposition in the st...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2012
ISSN: 0003-9942
DOI: 10.1001/archneurol.2012.764